引用一段枯燥的论文摘要(查到:该论文被教科书引用到医学教学中),该论文太长太多的实验数据和专业词汇,我是没看懂,请英文和医学专业好的同学努力,需要原文的话,我就贴出来。如下只是引用的序言,用于证明如上信息并非空穴来风,我只翻译部分段落大概意思,不许耻笑:
Abstract(摘要)
In our search for plants useful in the treatment of diarrhoea, we investigated the ethyl acetate extract of Baphia nitida (BN) using intestinal transit,
(我们研究的是植物在治疗腹泻中的作用,我们调查研究非洲小叶紫檀(简称BN)中提取的乙酸乙酯在消化系统运转中的作用)
enteropooling and gastric emptying tests in mice and rats. In the castor oil intestinal transit test, BN produced a significant (P < 0.05) dose dependent
decrease in propulsion with peristaltic index (PI) values of 56.85±6.76, 36.84±3.04 and 31.98±2.60%, respectively at doses of 100, 200 and
400 mg/kg vs. 89.33±6.28% for control. The effect at 400 mg/kg was significantly lower than that of morphine, 10 mg/kg, s.c. (20.29±3.78%),
and was antagonized by isosorbide dinitrate, IDN (150 mg/kg, p.o.) but not by yohimbine (1 mg/kg, s.c.). This effect was not potentiated by atropine
(1 mg/kg, s.c.). In the castor oil-induced diarrhoea test, BN produced a significant increase in onset of diarrhoea (103.40±8.74, 138.80±17.04 and
174.8±29.04 min, 100 to 400 mg/kg, vs. 47.60±8.76 min for control and 226.10±12.57 min for morphine). The severity of diarrhoea (diarrhoea
score) was dose dependently reduced (19.00±2.26, 17.04±1.89, 15.00±2.05, 100 to 400 mg/kg, vs. 31.40±2.11 for control and 7.7±2.2 for
morphine). This effect was not antagonized by IDN or yohimbine. The effect on severity was, however, potentiated by atropine. BN also reduced
the number and weight of wet stools but did not have any significant effect on intestinal fluid accumulation and gastric emptying. Results obtained
suggest that the ethyl acetate extract of Baphia nitida is endowed with antidiarrhoeal activity (研究结果明确显示光亮杂色豆木提取物乙酸乙酯被赋予了抗腹泻活性),possibly mediated by interference with the l-arginine
nitric oxide pathway(可能是由于氧化精氨酸酶的催化作用下) and synergistic with antagonistic action on muscarinic receptors.(增强了毒蕈硷在回肠之接受体的吸收的作用)
© 2008 Elsevier Ireland Ltd. All rights reserved.(爱尔兰爱丽斯威尔有限公司版权所有)
Keywords: Baphia nitida; Diarrhoea; Antidiarrhoeal activity; Intestinal transit; Enteropooling; Gastric emptying
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